From Buenos Aires, Villa de Merlo may be accessed through National Route 8 up to Río Cuarto, then turn into Provincial Route 1 up to the village. The land transportation system lets long-distance buses reach the city from all round the country.
Distances from Villa de Merlo to:
- Buenos Aires 758 km (along Route 8)
- Buenos Aires 918 km (along Route 7)
- Córdoba 250 km (along the Altas Cumbres path)
- Córdoba 350 km (through Cruz del Eje)
- Carlos Paz 200 km
- San Luis 187 km
- Mendoza 460 km
- Santa Rosa 570 km
- La Rioja 509 km
- Viedma 1166 km
- San Carlos de Bariloche 1650 km
- Santa Cruz 2020 km
- Ushuaia 3106 km